Given a latent position, the flow generator outputs a 3D deformation field mapping the canonical density to a particular conformation 3DFlex jointly learns a single canonical 3D density map of the particle, latent coordinates for each particle image, and a flow generator network.It can model non-rigid motion and flexibility of a protein molecule across its conformational landscape, and can use the motion model to combine signal from particle images in different conformations to improve refinement resolution in flexible regions. See the Data Cleanup guide for more details.ģD Flexible Refinement (3DFlex) ( Beta) is a motion-based deep generative model for continuous heterogeneity. Featuring a comprehensive Cleanup Data user interface, on-demand refreshing of project and job size statistics, data usage summaries in the project details sidebar, and new right-click menu options for selecting ancestors and descendants of jobs manually.Clear killed and failed jobs that take up disk space but can’t be further used.Clear intermediate results of iterative jobs across a project or workspace.Restack particles to remove filtered out junk particles and then automatically clear deterministic preprocessing jobs that can be re-run later if needed.Compact CryoSPARC Live sessions, removing preprocessing data but storing particle locations and parameters needed to restore the session later.Mark certain jobs as final and automatically clear everything except for jobs needed to replicate those results. Supporting five ways to clear up projects or workspaces: A new suite of tools to simplify the process of tracking and reducing disk space usage in CryoSPARC.
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